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Potential arthritis treatment prevents cartilage breakdown | MIT News | Massachusetts Institute of Technology

The catalytic cycle of dihydrolipoyl dehydrogenase is therefore completed, with the enzyme and its coenzymes in their oxidized forms

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Thiolutin treatment resulted in a pronounced induction of RPN4 , a transcription factor that coordinates expression of proteasome subunits and is activated under conditions of increased proteotoxic burden

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